Table S6.
Evaluation of plasma coagulation parameters of rats obtained in the toxicological evaluation at high doses of microparticles
| Parameter | Saline | PHBV–Ø | Ceftiofur–PHBV | PHBV–Ø | Ceftiofur–PHBV | PHBV–Ø | Ceftiofur–PHBV |
|---|---|---|---|---|---|---|---|
|
|
|
|
|
||||
| n=24 | 20 mg/kg of weight n=3 | 35 mg/kg of weight n=3 | 50 mg/kg of weight n=3 | ||||
| PT (%) | 100±16 | 120±7.6 | 123±7.7 | 123±3.8 | 119±6.3 | 117±10 | 114±3.4 |
| PTT (s)* | 18.3±1.8 | 15.7±0.7 | 15±0.1 | 14.6±0.4 | 16±0.9 | 16.3±0.4 | 14.5±0.3 |
Notes: Data presented as mean ± standard deviation.
*
Statistically significant differences compared to saline control (P<0.05).
Abbreviations: PT, prothrombin time; PTT, partial thromboplastin time; PHBV, poly(3-hydroxybutyrate-co-3-hydroxyvalerate); PHBV–Ø, empty microparticles.