Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Proposed model of the molecular function of PALMD. In response to DNA damage, p53 is stabilized and activated by phosphorylation at ser46. Activated p53 promotes PALMD expression. Accumulated PALMD in the cytoplasm localizes into the nucleus in response to DNA damage to induce apoptosis. In the other side, if PALMD is not induced, cells die with necroptosis-like cell death through ATP depletion
