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. 2014 May 22;5(5):e1247. doi: 10.1038/cddis.2014.222

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Copyright © 2014 Macmillan Publishers Limited

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 3.0 Unported License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/3.0/

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SPAG5 knockdown inhibited cervical cancer cell proliferation. Cell viability analysis of the growth curves of (a) transient SPAG5 knockdown HeLa and (b) shSPAG5 cells. (c) Transient SPAG5 knockdown HeLa soft agar colony showing inhibited colony quantity, size, and formation rates ( × 200). (d) SiHa shSPAG5 plate colony formation also showing inhibited colony formation rate. (e) G2/M arrest and (f) apoptosis induced by SPAG5 downregulation