Figure 5.

Increased senescence in tail hair follicles in Recql4^HD mice. Three pairs of wild-type and RTS male mice at the age of ∼40 weeks were used. (a) Hair loss on the tails of RTS mice. H&E staining (b) and SA-β-gal staining (c) were performed on frozen tail sections. (d) Increased DNA damage in tail hair follicles as assessed by expression of 53BP1. Quantitation was performed by comparing 53BP1-positive hair follicle cells per 100 DAPI-stained cells. **P<0.01; ***P<0.001. Bar indicates 150 μm