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. 2014 May 15;5(5):e1226. doi: 10.1038/cddis.2014.168

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Copyright © 2014 Macmillan Publishers Limited

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/

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Increased senescence and persistent DNA damage in bone marrow cells from Recql4^HD mice. (a) Senescence of bone marrow cells from two pairs of sibling wild-type and RTS mice at the age of 4 months was measured by SA-β-gal staining. The bar indicates 150 μM. (b) Expression of p21 was investigated by western blotting. (c) DNA-SCARS were identified by immunostaining bone marrow cells with p53 and PML antibodies. The bar indicates 20 μM