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. 2014 May 22;5(5):e1253. doi: 10.1038/cddis.2014.231

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Copyright © 2014 Macmillan Publishers Limited

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/

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CDC45 depletion does not affect induction of pSer10-histone H3 in S-phase HCT116 or HCT116 p53−/− cells depleted of CHK1. (a) Indicated cells pretreated with CHK1 or CHK1 and CDC45 siRNAs were exposed or not exposed to 2 mM thymidine (TdR) for 24 h before collection and analysis for pSer10-histone H3 (top panels, scatter plots) and DNA content (bottom panels) by flow cytometry. (b) Western blot analysis of CDC45 and CHK1 depletion in a representative experiment. β-Actin levels are presented as loading controls. (c) Mean values (± S.D.) for three independent experiments as presented above