Figure 1.

MST1 and MST2 expressions in the retina. (a and b) Western blot analysis for MST1 and MST2 in the retina. MST1 or MST2 protein is deleted in MST1^−/− or MST2^−/− mice, respectively. Both strains show no upregulation of the corresponding MST proteins. (c and d) Reverse transcriptional PCR for MST1 (c) or MST2 (d) in outer nuclear layer. MST1^−/− or MST2^−/− whole retina was used as a negative control. MST1 or MST2 mRNA is expressed in photoreceptor cells in B6129SF2 or C57BL/6 mice, respectively. (e and f) Retinal histology of untreated B6129F2 and MST1^−/− mice (e), or C57BL/6 and MST2^−/− mice (f). MST1^−/− and MST2^−/− mice display normal phenotype