Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2014 May 29;5(5):e1269. doi: 10.1038/cddis.2014.218

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2014 Macmillan Publishers Limited

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/

PMC Copyright notice

MST2, but not MST1, mediates photoreceptor cell death after RD. (a–d) TUNEL (green) and TO-PRO-3 (blue) staining at 24 h after RD (a and b) and time course of TUNEL-positive cell density in outer nuclear layer (ONL; n=6 each group and time point, c and d). There were no significant differences between B6129SF2 and MST1^−/− mice at any time points (c). Conversely, MST2^−/− mice displayed significantly less photoreceptor cell death than C57BL/6 mice 12, 24, 72 h after RD (**P<0.01 each, d). (e and f) ONL/INL (inner nuclear layer) ratio 7 days after RD (n=6 each). There was no significant difference between B6129SF2 and MST1^−/− mice (e). On the other hand, MST2^−/− mice showed significantly higher ONL/INL ratio than C57BL/6 mice (*P<0.05) (f). The graphs show mean±S.E.M.