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A proposed model for explaining the role and regulation of IRE1a in osteoblast differentiation. GEP induces the expression of IRE1a, whereas IRE1a inhibits BMP2-induced bone formation and GEP-mediated osteoblast differentiation. This inhibition depends on JunB. Thus, IRE1a, BMP2, GEP, and JunB constitute a regulatory feedback loop during bone formation. ‘→' and ‘
' indicate activation and repression, respectively
