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. 2014 May 15;5(5):e1227. doi: 10.1038/cddis.2014.186

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Copyright © 2014 Macmillan Publishers Limited

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/

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miRNAs modulated by Axl kinase in gefitinib-resistant lung cancer cells. (a) The sensitivity of HCC827, HCC827-Gef and Calu1 cells to gefitinib was examined by MTS analysis. (b) The relative expression of Axl in HCC827, HCC827-Gef and Calu1 cells by RT-qPCR analysis. The expression level was normalized by HPRT1. (c and d) The knockdown effects of Axl by esiRNA by RT-qPCR analysis. The expression level was normalized by HPRT1. (e and f) The relative expression of miR-374a and miR-548b in gefitinib-resistant lung cancer cells with silencing of Axl by RT-qPCR analysis. The expression level was normalized by U6 snRNA. Data were shown as the mean±S.D. of three independent experiments. *P<0.05