Figure 6.

Radiation induced a bystander effect through NF-κB-dependent pathways. (a) MDA-MB-231 cells were pretreated with BMS-345541 for 2 h, and then exposed to 2A-CM for 4 h. The protein expression was examined by western blot analyses. (b) MDA-MB-231 cells or HUVECs were pretreated with BMS-345541 for 2 h and then exposed to 2A-CM for 16 h. Cell invasion was examined using the Boyden chamber assay. The number of invading cells was quantified. **P<0.01 indicates significant differences between 2A-CM- and 10% FBS-treated cells. ^##P<0.01 indicates significant differences between inhibitor-treated and untreated cells