Table 1. Hydroxyl Radical-Scavenging and Quinone Reductase-Inducing Activities of the Isolated Active Compounds 1, 2, and 6.
| hydroxyl radical scavenging | QR induction |
|||
|---|---|---|---|---|
| compounda | ED50b (μM) | CDc (μM) | IC50d (μM) | CIe |
| 1 | 16.7 | 43.1 | >100 | >2.3 |
| 2 | 11.9 | 2.4 | >100 | >42.6 |
| 6 | >20 | 48.5 | >100 | >2.1 |
| quercetinf | 1.3 | |||
| l-sulforaphaneg | 0.77 | 16.7 | 21.7 | |
a
Compounds 3–5, 7, and 8 did not show hydroxyl radical-scavenging or QR-inducing activity at the concentrations tested.
b
ED50, concentration scavenging hydroxyl radical by 50%. Compounds with ED50 values of <20 μM are considered active.
c
CD, concentration required to double QR activity. Compounds with CD values of <20, 20–100, and >100 μM are considered significantly active, weakly active, and inactive, respectively.
d
IC50, concentration inhibiting cell growth by 50%.
e
CI, chemoprevention index (= IC50/CD).
f
Positive control for hydroxyl radical-scavenging assay.
g
Positive control for QR induction assay.