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. Author manuscript; available in PMC: 2015 Mar 20.
Published in final edited form as: Mol Cell. 2014 Mar 6;53(6):993–1004. doi: 10.1016/j.molcel.2014.01.032

Figure 3. Promoting cohesin binding in pRB-depleted cells.

Figure 3

Addition of exogenous nucleosides or co-depletion of Wapl does not alter A) the rate of proliferation, B) the cell cycle distribution, or C) the H4K20 methylation status at pericentromeric regions of cells depleted of pRB. D) However, both addition of exogenous nucleosides and co-depletion of Wapl are sufficient to enhance cohesin binding at pericentromeric heterochromatin in pRB-depleted cells. Error bars represent the SEM between individual biological replicates. See also Figure S4.