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. Author manuscript; available in PMC: 2015 Mar 20.
Published in final edited form as: Mol Cell. 2014 Mar 6;53(6):993–1004. doi: 10.1016/j.molcel.2014.01.032

Figure 7. Promoting Cohesion is sufficient to suppress CIN in a panel of non small cell lung cancer (NSCLC) lines.

Figure 7

A) NSCLC lines in which pRB function is compromised were treated with siRNA constructs targeting Wapl, or alternatively with a scrambled control for 36 h, fixed, stained (tubulin, ACA (kinet), and DAPI) and assessed for anaphase defects. Each NSCLC line analyzed exhibited massive segregation defects, including the presence of single and numerous lagging chromosomes and DNA bridges (representative images in panel A; arrow heads indicate kinetochores of lagging chromosomes). B) Wapl depletion suppressed the incidence of lagging chromosomes in each cell line.