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Aβ42 is toxic to central cholinergic fibers in control rats. Intrahippocampal infusion of synthetic Aβ42 for 28 days into hippocampus is detrimental to all central cholinergic axons in hippocampus. Using p75NTR immunohistochemistry, no cholinergic fibers can be identified in area CA1 (a–c) or DG (d–f) (N=5). Confocal images obtained at 20x. pyr, pyramidal cell; s. rad., stratum radiatum; s.l.m., stratum lacunosom moleculare; GC, granule cell
