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Evaluation of the impact of purine modifications on siRNA-mediated immune stimulation in human PBMC cultures. Design of the experiment and schematic depiction of siRNAs is discussed in the Fig. 1 legend. Modified guanosines present in control siRNA (A) or 728 siRNA (B) are compared with modified adenosines present in control siRNA (C) or 728 siRNA (D). TNFα levels for each siRNA are listed in Supplementary Tables S2 and S3.
