FIG. 1.

Combined and sex-specific NHP weight changes after intracerebral injection of M032 and saline. NHPs were weighed 1 week before and just before intracerebral injection of saline or M032 on day 1. The percent change in body weights from preinjection weights was averaged for all NHPs within each group and plotted (A), or plotted separately as male (B) and female (C) NHP groups, over the course of the 91-day study. Arrows indicate days in which cohorts within each group were sacrificed for additional endpoints. Error bars represent mean±SEM. For combined weights: preinjection to day 3; vehicle (n=6), M032 (n=12/dose). Days 4–31; vehicle (n=4), 1E6 M032 (n=8), 1E8 M032 (n=8 or 7; 1 animal euthanized moribund on day 16). Days 32–91; vehicle (n=2), 1E6 M032 (n=4), 1E8 M032 (n=3). NHP, nonhuman primate.