Table 1.
Vector Administration and Readministration to Dogs with Glycogen Storage Disease Type Ia
| 2nd Vector | 3rd Vector | 4th Vector | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dog (sex, follow-up) | Initial Neonatal vector | Pseudotype | Age (months) | Quantity | Reasona | Pseudotype | Age | Quantity | Reasona | Pseudotype | Age | Quantity | Reasona |
| W (female, 30 months) | AAV2/9, 2×1013 vp/kg | AAV2/8 | 15 | 1×1012 vp/kg | A, E, P | ||||||||
| Du (male, 3 months) | AAV2/9, 4×1013 vp/kg | — | |||||||||||
| F (male, 2 months) | AAV2/9, 4×1013 vp/kg | — | |||||||||||
| Ro (male, 2 months) | AAV2/9, 4×1013 vp/kg | AAV2/8 | 2 | 1×1013 vp/kg | A, E | ||||||||
| De (male, 18 months) | AAV2/9, 4×1013 vp/kg | AAV2/7 | 2 | 2×1012 vp/kg | H, S | AAV2/8 | 4 months | 1×1013 vp/kg | C | ||||
| H (female, 18 months) | AAV2/9, 4×1013 vp/kg | AAV2/7 | 3 | 2×1012 vp/kg | H | AAV2/8 | 5 months | 1×1013 vp/kg | H | ||||
| T (male, 10 months) | AAV2/9, 4×1013 vp/kg | AAV2/7 | 1 month | 1×1013 vp/kg | C | AAV2/8 | 2 months | 1×1013 vp/kg | C | AAV2/1 | 4.5 months | 2×1012 vp/kg | H |
| R (male, 58 months) | AAV2/8, 1×1013 vp/kg | AAV2/9 | 34 | 3×1012 vp/kg | A,E | AAV2/7 | 43 months | 1×1013 vp/kg | E, I | ||||
| L (female, 60 months) | AAV2/8, 1×1013 vp/kg | AAV2/9 | 36 | 3×1012 vp/kg | H | ||||||||
a
C, synchronize with cohort; E, emesis; H, hypoglycemia; I, anorexia; P, pancreatitis; S, seizures.