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The effect of ethnicity and genotype on nevirapine exposure
| Ethnicity | n | Nevirapine AUC0–6h (mg/L*h)1 | p | |
|---|---|---|---|---|
| African American | 6 | 18.3 ± 3.81 | 0.45 | |
| European American | 12 | 22.5 ± 2.69 | ||
| CYP2B6 516G>T | African Americans | |||
| GG | 1 | 4.23 | ND | |
| GT | 5 | 21.2 ± 5.63 | ||
| TT | 0 | - | ||
| European Americans | ||||
| GG | 4 | 20.5 ± 3.16 | 0.19 | |
| GT | 5 | 20.3 ± 2.82 | ||
| TT | 3 | 28.8 ± 3.64 | ||
| ABCB1 3435C>T | African Americans | |||
| CC | 2 | 7.31 ± 7.97 | 0.17 | |
| CT | 4 | 23.8 ± 12.8 | ||
| European Americans | ||||
| CC | 6 | 22.0 ± 3.03 | 0.96 | |
| CT | 5 | 22.2 ± 3.32 | ||
Mean ± SEM
