TABLE 4.
Grade Associations With Other Prognostic Factors
| Median Ki-67 for Negative Association (n) |
Median Ki-67 for Positive Association (n) |
|
|---|---|---|
| Positive lymph nodes | 1.70 (182) | 3.59 (135) |
| Distant metastases | 1.87 (281) | 6.97 (62) |
| Extending outside of pancreas | 1.57 (215) | 4.00 (128) |
| Necrosis | 1.76 (247) | 6.02 (65) |
| Perineural invasion | 1.80 (237) | 3.86 (105) |
| Small vessel invasion | 1.58 (226) | 3.83 (112) |
| Large vessel invasion | 1.90 (302) | 3.71 (34) |
| Positive margins | 2.00 (298) | 3.29 (45) |
| Recurrence | 1.56 (212) | 3.34 (63) |
n = number of observations used in each association calculation. T tests of the difference in average log(Ki-67) between the 2 averages were all associated with a P < 0.013. T tests were performed without assuming equal variances between groups and sample sizes were never less than 34.