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. Author manuscript; available in PMC: 2014 Jun 6.
Published in final edited form as: Genet Epidemiol. 2012 Sep 25;37(1):60–68. doi: 10.1002/gepi.21683

Figure 1.

Figure 1

In the upper panel, the normal curve represents a hypothetical distribution of the true log-ORs of disease association for all SNPs on a genome-wide association platform. The lower panel represents an alternative scenario where there are 3 “outlier” SNPs with extremely large population level log-ORs, with the other log-ORs again following a normal distribution. In both scenarios, the largest estimated log-OR is represented by the red cross. It is intuitively clear that it is more appropriate to shrink the estimated OR in the first scenario compared to the second.