Comparison 1. Type 1 diabetes: enhanced versus standard therapy.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Annualized risk difference (%)	3	1228	Annualized risk difference (%) (Fixed, 95% CI)	‐1.84 [‐2.56, ‐1.11]
2 Incidence of clinical neuropathy after 5 years: risk ratio	3	1228	Risk Ratio (M‐H, Fixed, 95% CI)	0.46 [0.33, 0.63]
3 Annual change in peroneal nerve motor conduction velocity	4	1371	Mean Difference (IV, Fixed, 95% CI)	0.61 [0.51, 0.71]
4 Annual change in median nerve motor conduction velocity	2	1241	Mean Difference (IV, Fixed, 95% CI)	0.46 [0.36, 0.57]
5 Annual change in ulnar nerve motor conduction velocity	2	134	Mean Difference (IV, Random, 95% CI)	1.49 [‐0.74, 3.71]
6 Annual change in vibration threshold in the feet	3	177	Std. Mean Difference (IV, Fixed, 95% CI)	0.32 [0.02, 0.62]