Comparison 2. Type 2 diabetes: enhanced versus standard therapy.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Annualized risk difference (%)	4	6669	Annualized risk difference (%) (Fixed, 95% CI)	‐0.58 [‐1.17, 0.01]
2 Incidence of clinical neuropathy after different times: risk ratio	4		Risk Ratio (M‐H, Fixed, 95% CI)	Totals not selected
3 Annual change in median nerve motor conduction velocity	1	99	Mean Difference (IV, Fixed, 95% CI)	0.56 [0.53, 0.60]
4 Annual change in vibration threshold in the feet	1	99	Mean Difference (IV, Fixed, 95% CI)	1.63 [1.34, 1.91]
5 Death	1	10251	Risk Ratio (M‐H, Fixed, 95% CI)	1.26 [1.06, 1.51]
6 Weight gain	1	10078	Risk Ratio (M‐H, Fixed, 95% CI)	1.96 [1.81, 2.13]