TABLE 4.

Uni- and multivariate analyses for clinicopathologic variables associated with DSS

Variable	Total	Number failed	1-year survival	5-year survival	Median survival	p log- rank	p multivariate	Hazard ratio	95 % CI
Center						0.9
FALP	8	4	0.62	0.46	21.1
YCU	13	7	0.69	0.35	25
MSKCC	48	32	0.77	0.29	28.1
Gender						0.19
Female	46	28	0.77	0.37	28.1
Male	23	15	0.66	0.09	25
Age (*, years)						0.1
≤68	34	19	0.78	0.36	43.8
>68	35	24	0.69	0.24	21.1
Race						0.9
Caucasian	37	25	0.76	0.29	28.2
Hispanic	11	7	1	0	13.2
Asian-Japanese	13	7	0.69	0.35	19
African-American	1	1	1	0.50	–
Pacific Islander	1	1	0.63	0.34	16.7
Asian-American	2	1	–	–	–
Indian	1	0	1	0	31.8
Unknown	3	1	0.74	0.28	28.4
Gallstones						0.09
Yes	53	36	0.69	0.25	24.1
No	16	7	0.87	0.52	–
Incidental diagnosis						0.24
Yes	27	17	0.84	0.32	44.3
No	42	26	0.67	0.33	21.1
Hepatic resection						0.19
Yes	64	41	0.7	0.27	24.6
No	5	2	1	0.66	88.8
Bile duct resection						0.06
Yes	41	29	0.68	0.21	19.0
No	28	14	0.81	0.42	44.4
Extra organ resection						0.7
Yes	10	5	0.76	0.38	31.8
No	56	35	0.74	0.30	28.1
Histology						<0.0001
Adenocarcinoma	62	37	0.79	0.32	28.1
Adenosquamous	5	4	0.40	0.20	11.8
Squamous	1	1	0	0	4.7
Grade						0.25
Well	13	6	0.76	0.44	43.8
Moderate	29	17	0.81	0.34	25
Poor	27	20	0.64	0.19	17.7
T stage						0.009	0.02	0.37	0.16–0.88
T1 + T2	30	13	0.79	0.43	52
T3 + T4	39	30	0.69	0.20	16.7
N stage						0.48
Positive	38	24	0.72	0.32	24.1
Negative	30	18	0.75	0.30	31.8
M stage						0.23
Yes	12	10	0.58	0.25	17.2
No	57	33	0.77	0.31	28.4
TNM stage						0.17
1 + 2	56	32	0.77	0.32	28.4
3 + 4	13	11	0.61	0.23	19
Lymphovascular  invasion						0.04	0.01	0.38	0.17–0.82
Yes	30	24	0.58	0.09	24.1
No	26	14	0.91	0.42	31.8
Perineural invasion						0.05
Yes	31	23	0.65	0.15	19.0
No	21	11	0.85	0.36	47.9
Adjuvant treatment						0.9
Yes	34	23	79	0.29	27.0
No	35	20	0.68	0.31	24.6
BCL2						0.37
Positive	5	3	0.8	0.6	67.9
Negative	57	37	0.71	0.26	24.1
p53						0.92
Positive	16	12	0.73	0.2	28.4
Negative	47	29	0.73	0.33	19.1
p21						0.47
Positive	11	8	0.63	0.27	13.3
Negative	51	33	0.75	0.28	27
p27						0.13
Positive	21	15	0.61	0.13	21.1
Negative	40	25	0.78	0.34	28.1
Cyclin D1						0.01	0.03	2.57	1.07–6.1
Positive	19	8	0.89	0.41	52
Negative	43	32	0.65	0.22	19
Mdm2						0.2
Positive	29	17	0.84	0.3	28.4
Negative	34	24	0.63	0.27	21.1
VEGF						0.5
Positive	40	26	0.76	0.33	27
Negative	20	13	0.61	0.22	13.3
PTEN						0.16
Lost	13	10	0.69	0.18	17.7
Present	40	22	0.75	0.35	42.1
PS6						0.004
Positive	16	4	0.79	0.68	–
Negative	45	36	0.69	0.17	19.1

^*Dichotomized around the median (68; range, 28–86)