Table 2.
Liver Enzymes, HDRS-17 Scores, and Comments of 17 Depressed Patients With Insomnia
| Patient | HDRS-17 |
HDRS-17 Item 4 |
HDRS-17 Item 5 |
HDRS-17 Item 6 |
|||||||||||||||
| Liver Enzyme |
Baseline | Wk 1 | Wk 2 | Wk 3 | Baseline | Wk 1 | Wk 2 | Wk 3 | Baseline | Wk 1 | Wk 2 | Wk 3 | Baseline | Wk 1 | Wk 2 | Wk 3 | Comments | ||
| Elevation | |||||||||||||||||||
| 1 | No | 7 | NA | NA | NA | 1 | NA | NA | NA | 0 | NA | NA | NA | 0 | NA | NA | NA | Improvement | |
| 2 | No | 20 | 12 | 7 | NA | 2 | 0 | 0 | NA | 2 | 1 | 1 | NA | 0 | 0 | 0 | NA | NA | |
| 3 | No | 27 | 19 | NA | NA | 2 | 2 | NA | NA | 2 | 2 | NA | NA | 0 | 0 | NA | NA | No improvement | |
| 4 | ALT | 23 | 16 | NA | NA | 2 | 2 | NA | NA | 1 | 1 | NA | NA | 0 | 0 | NA | NA | NA | |
| 5 | No | 20 | 14 | 17 | 13 | 2 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | Improvement | |
| 6 | No | 24 | 15 | 19 | 14 | 2 | 1 | 0 | 1 | 2 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | NA | |
| 7 | No | 21 | 22 | NA | NA | 1 | 1 | NA | NA | 1 | 1 | NA | NA | 2 | 1 | NA | NA | NA | |
| 8 | No | 20 | 18 | 18 | 16 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | NA | |
| 9 | No | 16 | 16 | 13 | 8 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 2 | 0 | 0 | 0 | 0 | Improvement | |
| 10 | No | 19 | 16 | 21 | 16 | 1 | 2 | 1 | 1 | 1 | 2 | 2 | 1 | 0 | 0 | 1 | 0 | NA | |
| 11 | No | 18 | 12 | 12 | 10 | 2 | 2 | 0 | 0 | 2 | 2 | 1 | 1 | 0 | 0 | 0 | 0 | NA | |
| 12 | No | 12 | 11 | 13 | NA | 1 | 1 | 0 | NA | 1 | 0 | 1 | NA | 0 | 0 | 0 | NA | Improvement | |
| 13 | ALT, AST, GGT | 21 | 16 | 14 | NA | 2 | 2 | 2 | NA | 2 | 2 | 2 | NA | 0 | 0 | 0 | NA | No improvement | |
| 14 | No | 22 | 16 | 8 | NA | 2 | 1 | 1 | NA | 2 | 2 | 1 | NA | 0 | 0 | 0 | NA | NA | |
| 15 | ALT, GGT | 21 | 15 | 13 | 8 | 2 | 0 | 0 | 0 | 2 | 0 | 2 | 1 | 0 | 0 | 0 | 0 | NA | |
| 16 | No | 18 | 19 | 17 | 13 | 2 | 2 | 2 | 2 | 2 | 2 | 1 | 1 | 0 | 0 | 1 | 0 | NA | |
| 17 | No | 16 | 13 | NA | NA | 2 | 1 | NA | NA | 2 | 1 | NA | NA | 0 | 0 | NA | NA | Improvement | |
Abbreviations: ALT = alanine aminotransferase, AST = aspartate aminotransferase, GGT = gamma-glutamyltransferase, HDRS-17 = 17-item Hamilton Depression Rating Scale, NA = not applicable.