. 2014 Jun 6;9(6):e97885. doi: 10.1371/journal.pone.0097885

Table 2. Propranolol pharmacokinetic data.

Subject	Intravenous							Oral
	Dose	C_max	T_max	AUC_0–∞	Cl	V_d	T_1/2	Dose	C_max	T_max	AUC_0–∞	T_1/2	F (%)
	(mg)	(ng×ml⁻¹)	(min)	(ng×min ×ml⁻¹)	(ml×min⁻¹)	(l×kg⁻¹)	(min)	(mg)	(ng×ml⁻¹)	(min)	(ng×min×ml⁻¹)	(min)
Patient 1	1.0	2.3	10	889	1125	8.1	293	40	90	120	39289	346	111
Patient 2	1.0	18.7	5	1818	550	5.0	477	40	59	90	48787	800	67
Patient 3	1.0	10.0	10	1310	763	5.0	257	40	52	480	55299	627	106
Patient 4^†	1.0	2.4	10	3029	330	5.2	824	40	156	180	143176	711	118
Patient 5	1.0	6.3	10	883	1133	13.4	485	40	25	90	22707	958	64
Patient 6	1.0	12.1	5	791	1265	9.3	358	40	50	90	14143	346	45
Patient 7	1.0	7.0	5	1752	571	4.9	504	40	63	180	72859	1029	104
Patient 8	1.0	7.4	5	7200	139	4.8	1718	40	62	180	88124	1237	31
Patient 9	1.0	2.2	10	1264	791	7.2	569	40	33	300	49476	1096	98
Patient 10	1.0	8.4	5	1432	698	10.0	934	40	20	60	17894	1362	31
Patient 11	1.0	10.6	5	1536	651	9.1	888	40	132	180	76244	838	124
Patient 12	1.2	5.9	10	1964^¥	606^¥	11.6	913	40	32	60	66527	1643	84
Patient 13	1.0	2.2	5	2540	394	8.2	934	40	53	180	42261	523	42
Patient 14	1.0	11.8	5	1004	996	4.9	275	40	82	60	44270	801	110
Patient 15	1.0	7.3	5	505	1981	8.2	193	40	59	60	23729	342	117
Summary statistics		7.6±1.1	5	1778±441	833±120	7.7±0.7^*	641±100^**		65±9	120	47260±5900^*	844±96^*	83±8^*
Control 1	1.0	7.2	10	785	1273	5.7	230	40	9	90	1332	85	4
Control 2	1.0	8.9	5	1469	681	2.6	198	40	22	180	8035	165	14
Control 3	1.0	14.1	5	856	1169	4.1	158	40	60	120	15816	176	46
Control 4	1.0	13.3	5	491	2038	3.4	90	40	30	180	9978	334	51
Control 5	1.0	18.1	5	1295	772	6.1	347	40	21	180	9471	310	18
Summary statistics		12.3±2	5	979±177	1187±241	4.4±0.7	205±43		28±9	180	8930±2320	214±47	27±9.2

Abbreviations: AUC = area under the concentration-time curve; Cl = clearance; C_max = peak concentration, C_min = trough concentration, F = oral bioavailability, T_1/2 = elimination half-life; T_max = time point of C_max; V_d = volume of distribution, NA = not available. Data are summarised as mean ± standard error of the mean or median as appropriate.

^†

Case excluded from AUC and Cl statistics due to the effect of concomitant treatment with ciprofloxacin (see main body of text for mechanistic explanation),

*p<0.01 vs. control subjects,

**p<0.05 vs. control subjects,

^¥

corrected for dose.