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. 2014 Jun 6;9(6):e97967. doi: 10.1371/journal.pone.0097967

Figure 6. Association between serum sex hormone levels and the presence of acute kidney injury.

Figure 6

The serum sex hormone levels are determined at the time of study enrollment, i.e. within 24 hours of the development of septic shock. (A) Receiver operator characteristic (ROC) curves of serum sex hormone levels and Acute Physiology and Chronic Health Evaluation II (APACHE II) scores for predicting AKI on enrollment. The areas under the ROC curves (AUCs) for progesterone, estradiol, and APACHE II scores were all greater than 0.5. (B) Serum estradiol and progesterone levels in pneumonia-related septic shock patients with severity of acute kidney injury stratified by RIFLE classification. Medians and interquartile ranges (IQR) of the estradiol (shaded bars) and progesterone levels (solid bars) are shown. Statistical significance was evaluated with the two-sided Mann-Whitney U test. Extreme values are not shown.