Table 1. Demographic characteristics of patients with pneumonia-related septic shocka.
| Overall | 28-day mortalityb | |||
| Survivors | Non-survivors | p valuec | ||
| Patient numbers | 107 | 57 | 50 | |
| Age, years | 79.1 (11.1) | 78.2 (10.4) | 80 (11.8) | 0.41 |
| Male gender | 92 (86%) | 48 (84.2%) | 44 (88%) | 0.57 |
| Comorbidity | ||||
| Obstructive airway disease | 25 (23.4%) | 13 (22.8%) | 12 (24%) | 0.88 |
| Interstitial lung disease | 11 (10.3%) | 6 (10.5%) | 5 (10%) | 0.93 |
| Congestive heart failure | 13 (12.1%) | 8 (14%) | 5 (10%) | 0.52 |
| Diabetes mellitus | 29 (27.1%) | 14 (24.6%) | 15 (30%) | 0.53 |
| Chronic renal insufficiency | 18 (16.8%) | 8 (14%) | 10 (20%) | 0.41 |
| Pathogens in sputum culture | ||||
| Gram-positive bacteria | 26 (24.3%) | 15 (26.3%) | 11 (22%) | 0.60 |
| Gram-negative bacteria | 85 (79.4%) | 49 (86%) | 36 (72%) | 0.08 |
| Disease severity | ||||
| APACHE II score | 27.8 (7.5) | 23.5 (4.6) | 32.8 (7.1) | <0.001 |
| PaO2/FiO2 ratio | 190.7 (101.3) | 222.6 (95.5) | 156.2 (96.8) | 0.001 |
| Organ dysfunctiond | ||||
| AKI | 58 (54.2%) | 25 (43.9%) | 33 (66%) | 0.022 |
| Hematologic dysfunction | 44 (41.1%) | 19 (33.3%) | 25 (50%) | 0.08 |
| Metabolic acidosis | 29 (27.1%) | 5 (8.8%) | 24 (48%) | <0.001 |
| ARDS | 60 (56.1%) | 23 (40%) | 37 (74%) | <0.001 |
| No. of organ dysfunctions | ||||
| ≥2 organ failure (including shock) | 90 (84.1%) | 43 (75.4%) | 47 (94%) | 0.009 |
| ≥3 organ failure (including shock) | 51 (47.7%) | 15 (26.3%) | 36 (72%) | <0.001 |
| ≥4 organ failure (including shock) | 29 (27.1%) | 4 (7%) | 25 (50%) | <0.001 |
| SOFA score | 11.4 (2.7) | 10.5 (2.3) | 12.5 (2.8) | <0.001 |
| Patients with second source of infection | 19 (17.8%) | 13 (22.8%) | 6 (12%) | 0.14 |
a
Data are presented as n (%), except for age, APACHE II score, PaO2/FiO2 ratio, SOFA score, hospital LOS and ICU LOS, which are presented as mean (standard deviation).
b
Pneumonia with septic shock patients were divided according to survival status at day 28.
c
p value represents differences between survivors and non-survivors of pneumonia-related septic shock.
d
Organ dysfunction was determined on the day of enrollment.
AKI, acute kidney injury; ARDS, adult respiratory distress syndrome; APACHE II, Acute Physiology and Chronic Health Evaluation II; CAP, community-acquired pneumonia; HAP, hospital-acquired pneumonia; SOFA, Sequential Organ Failure Assessment.