Table 3. Associations between ER-status, PR-status, HER2-status and the 18-gene vascular invasion signature score (mean signature score is given).

	ER			PR			HER2
	Neg	Pos	p-value1	Neg	Pos	p-value1	Neg	Pos	p-value1
GSE22358 (N = 154)	2.53	−1.44	<0.001	1.27	−1.14	0.015	−0.12	2.21	0.041
GSE26639 (N = 226)	1.71	−1.12	<0.001	1.12	−1.52	<0.001	−0.41	0.68	NS
GSE20271 (N = 178)	0.52	−0.52	0.045	0.58	−0.77	0.006	−0.08	0.12	NS
GSE 20194 (N = 230)	1.87	−1.15	<0.001	0.84	−0.98	0.003	−0.19	1.00	0.071
GSE25066 (N = 508)	1.54	−1.08	<0.001	1.11	−1.19	<0.001	-	-	-
GSE7849 (N = 78)	0.75	−0.52	NS	0.89	−0.79	0.038	-	-	-
GSE5460 (N = 129)	2.07	−1.44	<0.001	-	-	-	−0.59	1.87	0.016

¹Mann-Whitney U test, significance level 0.05.