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. 2014 Jun 6;9(6):e98932. doi: 10.1371/journal.pone.0098932

Figure 2. Assessment of β-cell area scores, islet size, and β-cell density.

Figure 2

Correlation between the median of manually obtained area scores and the median of automated area scores per patient in the whole cohort (non-diabetic patients and type 2 diabetic patients) for TMEM27 (A), BACE2 (B), and insulin (C). Median area scores of all non-diabetic patients vs. all type 2 diabetic patients for TMEM27 (D), BACE2 (E), and insulin (F). Median islet size of all non-diabetic patients vs. all type 2 diabetic patients assessed either by TMEM27/glucagon (G), BACE2/glucagon (H), or insulin/morphology (I). Median β-cell density of all non-diabetic patients vs. all type 2 diabetic patients assessed either by TMEM27 (J) or BACE2 positive cells (K). Values in Figure D-K were assessed by the automated pipeline.