Table 2. Univariate and multivariate analyses of the associations between prognostic variables and disease-free survival or overall survival in cervical cancer.
Disease-free Survival hazard ratio [95% CI], P value | Overall Survival hazard ratio [95% CI], P value | |||
Univariate analysis | Multivariate analysis | Univariate analysis | Multivariate analysis | |
Age | 0.99 [0.97–1.02], 0.923 | NA | 0.98 [0.94–1.03], 0.583 | NA |
FIGO stage | 5.32 [2.76–10.24], <0.001 | 1.88 [0.79–4.46], 0.153 | 3.27 [1.32–8.07], 0.010 | 3.26 [1.28–8.31], 0.013 |
Cell type (non-SCC) | 1.15 [0.50–2.63], 0.732 | NA | 2.68 [1.06–6.76], 0.035 | 2.72 [1.06–6.98], 0.037 |
Tumor grade (poor) | 1.98 [1.03–3.81], 0.040 | 1.64 [0.76–3.53], 0.207 | 2.40 [0.96–5.97], 0.060 | NA |
Tumor size (>4 cm) | 2.43 [1.27–4.65], 0.007 | 1.93 [0.84–4.40], 0.117 | 1.83 [0.74–4.54], 0.188 | NA |
LN metastasis | 4.97 [2.38–10.38], <0.001 | 2.57 [1.13–5.87], 0.024 | 2.23 [0.76–6.47], 0.141 | NA |
SCC Ag+ | 1.45 [0.71–2.96], 0.307 | NA | 1.80 [0.69–4.68], 0.225 | NA |
SCP3+ | 5.14 [1.82–14.52], 0.002 | 5.52 [1.78–17.11], 0.003 | 4.63 [1.07–20.01], 0.040 | 3.50 [0.79–15.44], 0.097 |
pAKT+ | 4.89 [1.90–12.58], 0.001 | 3.62 [1.19–11.05], 0.023 | 4.34 [1.27–14.86], 0.019 | 3.60 [1.04–12.42], 0.043 |
SCP3+/pAKT+ | 4.97 [2.34–10.53], <0.001 | 4.98 [1.90–13.01], 0.001 | 4.16 [1.51–11.46], 0.006 | 3.38 [1.21–9.43], 0.020 |
CI, confidence interval; FIGO, International Federation of Gynecology and Obstetrics; SCC, squamous cell carcinoma; LN, lymph node; NA, not applicable.