Table 4. Univariate and multivariate Cox regression survival analysis in HCC patients.
| Univariate analysis | Multivariate analysis | ||||||
| N | 3-year survival (%) | 5-year survival (%) | p | HR | 95% CI | p | |
| Sex (male/female) | 2054/600 | 61/63 | 48/50 | 0.283 | |||
| Age (≤65/>65 years) | 1362/1292 | 61/61 | 52/46 | 0.254 | |||
| HBsAg (negative/positive) | 1187/1467 | 61/61 | 46/51 | 0.54 | |||
| Creatinine (≤1.0/>1.0 mg/dL) | 1563/1091 | 64/56 | 53/43 | <0.001 | 1.226 | 1.079–1.392 | 0.002 |
| Sodium (≤139/>139 mmol/L) | 1513/1141 | 53/71 | 44/55 | <0.001 | |||
| AFP (≤50/>50 ng/mL) | 1333/1321 | 73/47 | 58/38 | <0.001 | 1.679 | 1.469–1.919 | <0.001 |
| TTV (≤50/>50 cm3) | 1325/1329 | 75/44 | 61/33 | <0.001 | 1.544 | 1.326–1.798 | <0.001 |
| Performance status (ECOG 0/1–4) | 1536/1118 | 74/38 | 61/19 | <0.001 | 1.959 | 1.679–2.287 | <0.001 |
| Vascular invasion (No/Yes) | 1726/928 | 70/39 | 56/34 | <0.001 | 1.703 | 1.467–1.977 | <0.001 |
| Treatment(curative/non-curative) | 1242/1412 | 78/42 | 65/30 | <0.001 | 2.319 | 2.005–2.681 | <0.001 |
| Modified CTP class | <0.001 | ||||||
| 0 | 441 | 80 | 71 | 1 | |||
| A | 1483 | 67 | 52 | 1.739 | 1.395–2.168 | <0.001 | |
| B | 583 | 36 | 26 | 3.120 | 2.442–3.986 | <0.001 | |
| C | 147 | 17 | 15 | 5.107 | 3.758–6.940 | <0.001 | |
Abbreviations: HCC, hepatocellular carcinoma; HR, hazard ratio; CI, confidence interval; HBsAg, hepatitis B surface antigen; AFP, α-fetoprotein; TTV, total tumor volume; ECOG, Eastern Cooperative Oncology Group; CTP, Child-Turcotte-Pugh.