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. 2014 Jun 6;9(6):e99115. doi: 10.1371/journal.pone.0099115

Table 6. The proposed criteria for original and modified models of the CLIP and TIS staging systems.

Prognostic predictors for hepatocellular carcinoma patients Scores
Tumoral factor Liver function Tumor behavior
Total tumorvolume Tumor numberand size Original Child-Turcotte-Pugh (CTP) classification Modified CTPclassification α-fetoprotein Vascularinvasion
<50/50–250/250–500/>500 Single and <50% liver span/multipleand <50% liver span/≧50% liver span A/B/C 0/A/B/C 0/A/B-C 0/A–B/C <400/>400 Absence/presence
Scores 0/1/2/3 0/1/2 0/1/2 0/1/2/3 0/1/2 0/1/2 0/1 0/1
CLIP V V V V 0–6
Modified CLIP Model A V V V V 0–7
Modified CLIP Model B V V V V 0–6
Modified CLIP Model C V V V V 0–6
TIS V V V 0–6
Modified TIS Model A V V V 0–7
Modified TIS Model B V V V 0–6
Modified TIS Model C V V 0–6

Abbreviations: CTP, Child-Turcotte-Pugh; CLIP, Cancer of the Liver Italian Program; TIS, Taipei Integrated Scoring.