Table 2. Methylation profiles in children from non-obese parents at the DMRs of imprinted genes.
|
Baseline methylation percentage in children from non-obese parents | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
MEG3-IG |
MEG3 |
MEST |
NNAT |
PEG3 |
PLAGL1 |
SGCE/PEG10 |
||||||||
| % | s.e. | % | s.e. | % | s.e. | % | s.e. | % | s.e. | % | s.e. | % | s.e. | |
| CpG 1 | 47.4 | 0.9 | 51.1 | 1.4 | 45.6 | 0.5 | 61.5 | 0.8 | 36.0 | 0.4 | 62.8 | 1.3 | 50.2 | 0.5 |
| CpG 2 | 42.5 | 0.9 | 67.9 | 1.6 | 46.4 | 0.5 | 56.0 | 0.8 | 38.5 | 1.2 | 61.2 | 1.3 | 49.0 | 0.5 |
| CpG 3 | 60.2 | 0.9 | 73.4 | 1.1 | 45.8 | 0.5 | 53.0 | 0.7 | 38.3 | 0.4 | 61.3 | 1.3 | 50.9 | 0.5 |
| CpG 4 | 53.0 | 1.1 | 70.5 | 1.2 | 48.5 | 0.6 | 35.3 | 0.5 | 59.1 | 1.2 | 47.2 | 0.5 | ||
| CpG 5 | 75.5 | 0.8 | 41.0 | 0.4 | 58.6 | 1.0 | 49.4 | 0.7 | ||||||
| CpG 6 | 78.3 | 1.0 | 35.8 | 0.5 | 56.2 | 1.1 | 53.0 | 0.5 | ||||||
| CpG 7 | 83.0 | 0.6 | 35.9 | 0.4 | ||||||||||
| CpG 8 | 74.6 | 0.9 | 33.1 | 0.6 | ||||||||||
| CpG 9 | 39.8 | 0.4 | ||||||||||||
| CpG 10 | 41.2 | 0.6 | ||||||||||||
| Mean | 50.8 | 0.7 | 71.8 | 1.0 | 46.6 | 0.5 | 56.9 | 0.8 | 37.5 | 0.3 | 59.8 | 1.1 | 50.0 | 0.5 |
Abbreviations: MEG3, maternally expressed gene 3; MEST, mesoderm-specific transcript; NNAT, neuronatin; PEG3, paternally expressed gene 3; PLAGL1, pleiomorphic adenoma gene-like 1; SGCE/PEG10, epsilon sarcoglycan and paternally expressed gene 10.
The estimated means of methylation percentages for children born from non-obese parents are presented for each DMR, by the individual CpG site studied. The calculated mean for each DMR is shown at the bottom line.