Table 3. Multivariate analyses: DNA methylation at the DMRs in the offspring in relation to obesity of the parents.

	MEG3-IG			MEG3			MEST			NNAT			PEG3			PLAGL1			SGCE/PEG10
	β	s.e.	P	β	s.e.	P	β	s.e.	P	β	s.e.	P	β	s.e.	P	β	s.e.	P	β	s.e.	P
Model 1
Father obese	+0.38	1.43	0.79	+1.04	1.47	0.48	−2.50	0.84	0.003	−3.04	1.45	0.04	−1.70	0.62	0.007	+1.39	1.47	0.34	+1.26	0.99	0.10
Model 2
Mother obese	+0.20	1.26	0.87	−2.94	1.57	0.06	−0.98	0.66	0.14	−0.88	1.26	0.48	−0.02	0.56	0.97	+3.03	0.86	0.0005	+1.08	0.68	0.11
Model 3
Father obese	+0.34	1.71	0.84	+2.75	1.74	0.11	−2.57	0.95	0.008	−3.59	1.76	0.04	−1.71	0.61	0.005	+2.19	1.33	0.10	+1.26	0.80	0.12
Mother obese	+0.11	1.57	0.95	−3.42	1.69	0.04	+0.37	0.81	0.65	+0.85	1.60	0.59	+0.46	0.60	0.47	+2.58	1.00	0.01	+1.02	0.75	0.17

Abbreviations: MEG3, maternally expressed gene 3; MEST, mesoderm-specific transcript; NNAT, neuronatin; PEG3, paternally expressed gene 3; PLAGL1, pleiomorphic adenoma gene-like 1; SGCE/PEG10, epsilon sarcoglycan and paternally expressed gene 10.

Obesity was defined as BMI⩾30 kg m⁻². All the models were adjusted by age, race, education, smoking status of the mother, gender of the offspring, clusters of experimental tests and CpG sites measured. Model 1 includes paternal obesity, model 2 includes maternal obesity and model 3 includes both paternal and maternal obesity.