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. 2013 Nov 21;8(1):5–12. doi: 10.4161/chan.27107

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graphic file with name chan-8-5-g4.jpg — Figure 4. Comparison between EcMscS and TtMscS cytoplasmic domains. Upper panel shows a Coulombic charge distribution of a transverse section as viewed from the periplasmic side of TtMscS (PDB: 3T9N; left side) and EcMscS (PDB: 2VV5; right side). Regions of electronegativity (denoted as red) can be identified centered around D226/D229 and E187/E227, respectively. The lower panel shows the underside of the cytoplasmic domain of TtMscS (right side) EcMscS (left side) highlighting the β-barrel residue implicated in anion selectivity in TtMscS (kcal/(mol·e) at 298 K).