Figure 6. Conserved tension transmitting residues in EcMscS, HpMscS and TtMscS. (A) Open structure of EcMscS showing close association of F68 and L111/115. (B) Closed/inactivated structure of EcMscS showing dissociation of tension transmitting residues. (C) Illustration of similar position of a phenylalanine residue and leucine residues in closed structure of HpMscS. (D) In the closed structure of TtMscS the location of these residues may be switched. However, multiple alternative hydrophobic residues are present that may interact in a similar way to F68 and L111/115 in EcMscS.