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. 2014 May 18;3:251. doi: 10.1186/2193-1801-3-251

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© Verma et al.; licensee Springer. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.

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Impact of lipotoxic condition on glucose metabolism. (A) After lipotoxic treatment, myotubes were lysed and cellular pyruvate levels were measured (*** P < 0.001). (B) Lactate release from myotubes was measured in culture medium collected after lipotoxic treatment (* P < 0.05). (C) Cellular ATP levels (*** P < 0.001) and (D) glycogen storage (*** P < 0.001) were measured after lipotoxic treatment as described in Methods. After lipotoxic treatment, RNA was isolated and mRNA levels of glucose transporter Glut4/Slc2a4 (** P < 0.01; E) and Glut1/Slc2a1 (*** P < 0.001; F) were quantified using qPCR.