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Lipotoxic condition causes increased apoptosis and proteolysis in myotubes. After chronic lipotoxicity, MTT assay (A, ** P < 0.01) and caspase-3 activity assay (B, *** P < 0.001) were performed as described under Methods. Proteolysis was estimated by elevated release of proteins (C, * P < 0.05) and branched chain amino acids (BCAA) (D, * P < 0.05) form myotubes into culture medium and up-regulated expression of proteolysis marker Trim63 (E, *P < 0.05).
