Table 6.
Biological process, molecular function and pathway activated regarding ovarian stimulation protocol
| Biological process | P-value | Molecular function | P-value | Pathway | P-value |
|---|---|---|---|---|---|
| hFSH vs. PP | |||||
| Proteolysis | 1,78E-03 | mRNA splicing factor | 4,35E-03 | p38 MAPK pathway | 1,39E-03 |
| Protein metabolism and modification | 5,20E-03 | mRNA processing factor | 8,47E-03 | ||
| mRNA splicing | 1,73E-02 | Nucleic acid binding | 4,51E-02 | ||
| Pre-mRNA processing | 3,06E-02 | ||||
| hFSH + PP vs h FSH | |||||
| Cholesterol metabolism | 4,01E-03 | Hsp 70 family chaperone | 2,04E-04 | Apoptosis signaling pathway | 1,41E-02 |
| Protein complex assembly | 4,01E-03 | Chaperone | 2,45E-02 | ||
| Protein metabolism and modification | 6,43E-03 | Other RNA-binding protein | 2,88E-02 | ||
| Proteolysis | 9,67E-03 | Other G-protein modulator | 4,28E-02 | ||
| Cell surface receptor mediated signal transduction | 2,30E-02 | ||||
| Steroid metabolism | 2,63E-02 | ||||
| Protein folding | 2,71E-02 | ||||
| Stress response | 3,10E-02 | ||||
| Apoptosis | 3,63E-02 | ||||
| Signal transduction | 3,73E-02 | ||||
| hFSH + PP vs. PP | |||||
| Nucleoside, nucleotide and nucleic acid metabolism | 7,53E-05 | Phosphatase inhibitor | 2,47E-05 | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | 4,76E-03 |
| mRNA transcription | 1,76E-04 | Phosphatase modulator | 1,30E-04 | p38 MAPK pathway | 5,47E-03 |
| mRNA transcription regulation | 1,46E-03 | Select regulatory molecule | 1,62E-03 | Inflammation mediated by chemokine and cytokine signaling pathway | 2,17E-02 |
| DNA replication | 3,19E-03 | Nucleic acid binding | 1,90E-03 | ||
| DNA metabolism | 4,76E-03 | Translation initiation factor | 6,03E-03 | ||
| Developmental processes | 6,16E-03 | Other miscellaneous function protein | 8,59E-03 | ||
| Cholesterol metabolism | 7,43E-03 | Other G-protein modulator | 1,05E-02 | ||
| Chromatin packaging and remodeling | 1,02E-02 | Translation factor | 1,79E-02 | ||
| Cell structure and motility | 2,04E-02 | Other membrane traffic protein | 2,08E-02 | ||
| Signal transduction | 2,20E-02 | Transcription factor | 3,70E-02 | ||
| Protein phosphorylation | 3,57E-02 | Transcription cofactor | 4,03E-02 | ||
| Cell cycle | 4,10E-02 | G-protein modulator | 4,11E-02 | ||
| Cell proliferation and differentiation | 4,38E-02 | Isomerase | 4,47E-02 | ||
| Ligand-mediated signaling | 4,52E-02 | ||||
| Steroid metabolism | 4,70E-02 | ||||