Table 1.
The characteristics of eligible studies of meta-analysis
| First author (year) | Ethnicity (country) | Sample size (case/control) | Genotyping methods | Source of control | PCOS diagnosis | Matching criteria | HWE P value |
|---|---|---|---|---|---|---|---|
| Waterworth(1) (1997) | Caucasian (London) | 59/54 | NR | PB | Ultrasound symptoms | NR | 0.142 |
| Waterworth(2) (1997) | Caucasian (London) | 39/39 | NR | FB | Ultrasound symptoms | NR | 0.006 |
| Vankova (2002) | Caucasian (Česko) | 38/22 | PCR-RFLP | PB | NIH criteria | Age, Weight | 0.670 |
| Powell (1) (2005) | Caucasian (Britain) | 185/1062 | ARMS assay, Pyrosequencing | PB | Rotterdam criteria | Age | 0.321 |
| Powell (2) (2005) | Caucasian (Finland) | 72/1069 | ARMS assay, Pyrosequencing | PB | Ultrasound symptoms | Age, BMI, Weight | 0.564 |
| Powell (3) (2005) | Caucasian (Finland) | 458/1069 | ARMS assay, Pyrosequencing | PB | symptoms | Age, BMI, Weight | 0.564 |
| Kadri (2007) | Caucasian (Estonia) | 30/75 | PCR-RFLP | HB | Rotterdam criteria | Age, BMI | 0.182 |
| P Perk (2008) | Caucasian (Slovenia) | 117/108 | TaqMan assay | PB | Rotterdam criteria | Age | 0.811 |
| Y-P Xu (2009) | Asian (China) | 216/192 | PCR-RFLP | HB | Rotterdam criteria | Age | 0.982 |
| Q-F Zhang (2010) | Asian (China) | 130/130 | PCR-RFLP | HB | Rotterdam criteria | NR | 0.055 |
| Zhen Liu (2011) | Asian (China) | 55/50 | PCR-RFLP | HB | Rotterdam criteria | Age | 0.006 |
| J-H Yun (2012) | Asian (Korea) | 218/141 | PCR-RFLP | HB | Rotterdam criteria | BMI,Weight | 0.292 |
| L. Skrgati (2013) | Caucasian (Croatia) | 150/170 | TaqMan assay | PB | Rotterdam criteria | Age, BMI | 0.674 |
ARMS amplification refractory mutation system, PB population-base, HB hospital-base, FB family-base, NR not reported
Data in boldface represent P<0.05