Table 3.
Baseline characteristics according to the CHADS2 score
| Characteristic | Overall (n = 971) | CHADS2= 2 [n = 475 (49)] | CHADS2= 3 [n = 283 (29)] | CHADS2= 4–6 [n = 213 (22)] | P-trend |
|---|---|---|---|---|---|
| Age, years | 73 (65, 79) | 70 (63, 77) | 75 (67, 80) | 76 (70, 80) | <0.001 |
| Age ≥75 years | 442 (45.5) | 168 (35.4) | 145 (51.2) | 129 (60.6) | <0.001 |
| Gender, F | 334 (34.4) | 150 (31.6) | 106 (37.5) | 78 (36.6) | 0.13 |
| Race, Caucasian | 896 (92.3) | 440 (92.6) | 260 (91.9) | 196 (92.0) | 0.74 |
| Type of AF | 0.09 | ||||
| Paroxysmal | 319 (32.9) | 155 (32.6) | 104 (36.8) | 60 (28.2) | |
| Persistent | 203 (20.9) | 108 (22.7) | 57 (20.1) | 38 (17.8) | |
| Permanent | 449 (46.2) | 212 (44.6) | 122 (43.1) | 115 (54.0) | |
| History of | |||||
| Heart failure | 521 (53.7) | 222 (46.7) | 176 (62.2) | 123 (57.8) | 0.001 |
| Hypertension | 892 (91.9) | 421 (88.6) | 264 (93.3) | 207 (97.2) | <0.001 |
| Diabetes mellitus | 340 (35.0) | 92 (19.4) | 142 (50.2) | 106 (49.8) | <0.001 |
| Stroke or TIA | 258 (26.6) | 26 (5.5) | 60 (21.2) | 172 (80.8) | <0.001 |
| Coronary HD | 359 (37.0) | 146 (30.7) | 111 (39.4) | 102 (47.9) | <0.001 |
| Tobacco, ever | 489 (50.4) | 236 (49.7) | 153 (54.1) | 100 (47.0) | 0.74 |
| Obese | 407 (41.9) | 189 (39.8) | 130 (45.9) | 88 (41.3) | 0.47 |
| CKDa | 325 (33.9) | 118 (25.2) | 108 (38.6) | 99 (47.1) | <0.001 |
| Creatinine clearance | 71 (55, 92) | 77 (60, 100) | 68 (53, 91) | 62 (48, 79) | <0.001 |
| Heart rate, b.p.m. | 72 (63, 82) | 70 (62, 82) | 72 (64, 83) | 72 (65, 80) | 0.14 |
| Systolic BP, mmHg | 130 (120, 140) | 130 (120, 140) | 130 (119, 142) | 130 (118, 142) | 0.56 |
| Diastolic BP, mmHg | 78 (70, 83) | 78 (70, 83) | 78 (70, 84) | 77 (69, 82) | 0.18 |
Data presented as counts (percentages) or median (inter-quartile ranges) for categorical and continuous variables, respectively.
TIA, transient ischaemic attack; HD, heart disease; CKD, chronic kidney disease; BMI, body mass index.
aCKD defined by creatinine clearance <60 mL/min at randomization.