Table 1.
Study sample characteristics (N=1965).
| Clinical Characteristics | TOTAL (n=1965) | All CMB (n=173) | Lobar only (n=109) | Deep only (n=38) | Any Deep [deep + mixed] (n=64) | No CMB (n=1792) |
|---|---|---|---|---|---|---|
| Men | 904(46.0) | 100 (57.8) | 66 (60.6) | 19 (50.0) | 34 (53.1) | 804 (44.9) |
| Age(years) at Exam closest to baseline-MRI | 66.5 (11.0) | 74.2 (9.4) | 73.1(10.0) | 75.7 (8.8) | 76.1 (8.0) | 65.8 (10.9) |
| Age(years) at MRI | 67.2 (10.7) | 74.8 (9.1) | 73.6 (9.8) | 76.3 (8.1) | 76.7 (7.5) | 66.5 (10.6) |
| Time between exam and MRI(years) | 0.67 (1.2) | 0.60 (1.4) | 0.58 (1.3) | 0.67 (1.8) | 0.64 (1.6) | 0.68 (1.2) |
|
Vascular risk factors
| ||||||
| Hypertension | 1101 (56.0) | 135 (78.0) | 79 (72.5) | 32 (84.2) | 56 (87.5) | 966 (53.9) |
| Total-Cholesterol(mg/dL) | 191 (37) | 179 (39) | 179 (38) | 183 (43) | 181 (33) | 192 (37) |
| LDL(mg/dL) | 110 (32) | 101 (32) | 100 (31) | 104 (34) | 103 (33) | 111 (32) |
|
Medication Use
| ||||||
| Aspirin | 799 (40.7) | 94 (54.3) | 58 (53.2) | 24 (63.2) | 36 (56.3) | 705 (39.4) |
| Antiplatelet | 564 (28.7) | 71 (41.0) | 42 (38.5) | 19 (50.0) | 29 (45.3) | 493 (27.5) |
| Anticoagulant | 86 (4.4) | 19 (11.0) | 12 (11.0) | 2 (5.3) | 7 (10.9) | 67 (3.7) |
| Statin | 606 (30.9) | 82 (47.4) | 49 (45.0) | 19 (50.0) | 33 (51.6) | 524 (29.3) |
|
APOE Status
| ||||||
| Any ε4 | 449 (23.3) | 44 (25.7) | 33 (30.8) | 8 (21.1) | 11 (17.2) | 405 (23.1) |
| ε 3/ε3 | 1219 (63.2) | 108 (63.2) | 59 (55.1) | 26 (68.4) | 49 (76.6) | 1111 (63.2) |
*
values are mean (SD) for continuous variables and n (%) for categorical variables