Table 2.
Logistic regression models for the association between vascular risk factors, medication use and prevalent CMB.
| All CMB (n=173) | Lobar only (n=109) | Deep only (n=38) | Any Deep [deep + mixed] (n=64) | |||||
|---|---|---|---|---|---|---|---|---|
|
| ||||||||
| OR | (95% CI) | OR | (95% CI) | OR | (95% CI) | OR | (95% CI) | |
| Age(years) | 1.08 | (1.06–1.10) | 1.07 | (1.05–1.09) | 1.10 | (1.06–1.13) | 1.11 | (1.08–1.14) |
| Men vs. Women | 1.82 | (1.31–2.51) | 1.99 | (1.33–2.97) | 1.38 | (0.72–2.65) | 1.57 | (0.94–2.63) |
|
| ||||||||
| Vascular risk factors | ||||||||
|
| ||||||||
| Hypertension Stage 1 or higher† | 1.71 | (1.15–2.54) | 1.32 | (0.84–2.10) | 2.45 | (0.99–6.09) | 3.13 | (1.45–6.78) |
| Total-cholesterol(mg/dL) | 1.00 | (0.99–1.00) | 1.00 | (0.99–1.01) | 0.99 | (0.98–1.01) | 1.00 | (0.99–1.01) |
| Total-cholesterol<10th percentile* | 1.91 | (1.20–3.03) | 1.99 | (1.14–3.44) | 2.25 | (0.93–5.49) | 1.76 | (0.84–3.70) |
| LDL-cholesterol<10th percentile* | 1.28 | (0.75–2.19) | 1.69 | (0.94–3.06) | 0.53 | (0.12–2.29) | 0.63 | (0.22–1.82) |
|
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| Medication Use | ||||||||
|
| ||||||||
| Statin use | 1.67 | (1.20–2.31) | 1.52 | (1.02–2.27) | 1.83 | (0.95–3.54) | 1.92 | (1.15–3.21) |
| Aspirin use | 1.27 | (0.91–1.77) | 1.22 | (0.81–1.82) | 1.93 | (0.97–3.83) | 1.39 | (0.82–2.34) |
| Antiplatelet use | 1.35 | (0.96–1.91) | 1.20 | (0.79–1.83) | 2.14 | (1.08–4.25) | 1.71 | (1.00–2.92) |
| Anticoagulant use | 1.72 | (0.97–3.03) | 1.76 | (0.89–3.48) | 0.70 | (0.16–3.06) | 1.54 | (0.65–3.65) |
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| APOE | ||||||||
|
| ||||||||
| Any APOE ε4 vs. none | 1.29 | (0.88–1.87) | 1.62 | (1.05–2.50) | 1.01 | (0.45–2.24) | 0.79 | (0.40–1.55) |
Models are adjusted for age, sex, interval examination-brain MRI.
†
Hypertension stage-1 based on JNC-7 definition: SBP ≥140mmHg or DBP ≥90mm Hg or hypertension treatment regardless of blood pressure.
*
Referent is ≥10th percentile. Percentile cutoffs were defined in the total sample. Total-Cholesterol 10thpercentile is 162mg/dL and 86mg/dL for LDL-cholesterol. Note: All cholesterol levels represent the average over three exams, corresponding to a ~12-year period prior to the participant’s index exam.