Skip to main content
. Author manuscript; available in PMC: 2015 Jun 2.
Published in final edited form as: Annu Rev Biochem. 2014 Mar 5;83:441–466. doi: 10.1146/annurev-biochem-060713-035524

Figure 5.

Figure 5

Functions of base-pair reshuffling dynamics. (A) In the HIV-1 TAR apical loop, the minor CS sequesters residues involved in HIV Tat and Cyclin T1 binding during transcriptional activation (54). (B) In the major CS of the ribosomal A-site, A92 and A93 are free to interact with and stabilize cognate mRNA/tRNA minihelices during decoding, indicated by the gray dashed arrow and alternative A92/A93 conformation. The minor CS sequesters these residues, inhibiting decoding and also disrupting the B2a inter-subunit bridge (54).