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. Author manuscript; available in PMC: 2015 Jun 1.
Published in final edited form as: J Cardiovasc Pharmacol. 2014 Jun;63(6):533–543. doi: 10.1097/FJC.0000000000000078

Figure 1. PP2 slows and prevents ISO stimulation of action potentials in isolated sinus node myocytes.

Figure 1

(A) spontaneous action potentials (APs) recorded from a sinus node myocyte. (B) PP2 at 2 μM reduced the number of APs that were spontaneously fired. (C) Washout of PP2 partially recovered the number of APs. Similar experiments were repeated in an additional 4 cells. Dash lines indicate 0mV. (D) APs recorded from a different sinus node myocyte pretreated with 2 μM PP2 for 2–4 min. (E) In the presence of PP2, ISO (10 nM) failed to increase the number of APs. Similar experiments were repeated in an additional 3 cells. (F) APs recorded from a different myocyte incubated with PP3 (2 μM) for 5 min. Similar results were obtained in an additional 4 cells.