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Effect of ATX inhibitor hits on cancer cell invasion in vitro. A2058 human melanoma cells were applied to Matrigel-coated BD BioCoatTM chambers. ATX (0.1 nM) plus 1 μM of 18:1 LPC with or without 10 μM of the inhibitors was applied, and invasion was quantified 16 h later. For dose response curves, the inhibitors were applied at increasing concentrations ranging from 0.01 μM to 10 μM. The numbers shown are the mean of three experiments ± SD.
