Table 3.
Antiphospholipid Antibody | Arterial Thrombosis | Venous Thrombosis | All Thrombosis | |
---|---|---|---|---|
IgA anti- β2GPI |
Positive, % | 17.0 | 20.5 | 31.6 |
Negative, % | 10.4 | 15.3 | 23.3 | |
OR (95%CI) | 1.8 (1.1 - 2.8) | 1.4 (0.9 - 2.2) | 1.5 (1.1 - 2.2) | |
P | 0.018 | 0.103 | 0.027 | |
Adjusted OR (95% CI) † | 2.2 (1.1 - 4.4) | 1.6 (0.9 - 2.8) | 1.9 (1.1 - 3.3) | |
P | 0.021 | 0.120 | 0.016 | |
Isolated IgA anti- β2GPI |
Positive, % | 31.8 | 29.5 | 50.0 |
Negative, % | 10.6 | 15.6 | 23.6 | |
OR (95%CI) | 3.9 (2.0 - 7.7) | 2.3 (1.2 - 4.5) | 3.2 (1.8 - 6.0) | |
P | <0.001 | 0.015 | <0.001 | |
Adjusted OR (95% CI) † | 5.8 (2.3 - 15.2) | 2.3 (1.0 - 5.4) | 5.1 (2.2 - 12.4) | |
P | 0.0003 | 0.061 | 0.0003 |
P values represent comparisons of autoantibody-positive versus autoantibody-negative patients anti-β2GPI = anti- β2-glycoprotein I; OR = odds ratio; 95% CI = 95% confidence interval
Adjusted for age at visit, smoking, obesity (BMI), pregnancy at visit, oral contraceptives, end-stage renal disease (measured by serum creatinine level), hydroxychloroquine treatment, and non-steroidal anti-inflammatory drug treatment.