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. Author manuscript; available in PMC: 2014 Dec 1.
Published in final edited form as: Arthritis Rheum. 2013 Dec;65(12):3186–3193. doi: 10.1002/art.38131

Table 3.

Association of anti-β2GPI IgA positivity with thrombosis*

Antiphospholipid Antibody Arterial Thrombosis Venous Thrombosis All Thrombosis
IgA anti-
β2GPI		 Positive, % 17.0 20.5 31.6
Negative, % 10.4 15.3 23.3
OR (95%CI) 1.8 (1.1 - 2.8) 1.4 (0.9 - 2.2) 1.5 (1.1 - 2.2)
P 0.018 0.103 0.027
Adjusted OR (95% CI) † 2.2 (1.1 - 4.4) 1.6 (0.9 - 2.8) 1.9 (1.1 - 3.3)
P 0.021 0.120 0.016
Isolated IgA anti-
β2GPI		 Positive, % 31.8 29.5 50.0
Negative, % 10.6 15.6 23.6
OR (95%CI) 3.9 (2.0 - 7.7) 2.3 (1.2 - 4.5) 3.2 (1.8 - 6.0)
P <0.001 0.015 <0.001
Adjusted OR (95% CI) † 5.8 (2.3 - 15.2) 2.3 (1.0 - 5.4) 5.1 (2.2 - 12.4)
P 0.0003 0.061 0.0003
*

P values represent comparisons of autoantibody-positive versus autoantibody-negative patients anti-β2GPI = anti- β2-glycoprotein I; OR = odds ratio; 95% CI = 95% confidence interval

†

Adjusted for age at visit, smoking, obesity (BMI), pregnancy at visit, oral contraceptives, end-stage renal disease (measured by serum creatinine level), hydroxychloroquine treatment, and non-steroidal anti-inflammatory drug treatment.