Figure 4. The skewed T cell distribution identifying CVID-Mgat2^ΔM/ΔM mice is due to selective naïve T cell lymphopenia.

Mgat2^wt/wt or naïve and CVID-Mgat2^ΔM/ΔM mice were used to determine total CD4⁺ and CD8⁺ T cell counts in A) blood and B) spleen. Naïve (CD44^low) CD4⁺ and CD8⁺ T cell counts in C) blood and D) spleen. Effector/memory (CD44^hi) CD4⁺ and CD8⁺ T cell counts E) in blood and F) spleen. G) Total thymocyte counts and H) the stages of thymocyte development based on CD4 and CD8 expression were similar suggesting that loss of naïve T cells is not due to thymic dysfunction in CVID-Mgat2^ΔM/ΔM mice. *p<0.05, **p<0.01, ***p<0.001